A Continuous Conical-Mill Operation for Dry Coating of Pharmaceutical Powders: The Role of Processing Time

Over the last decade, conical mill has emerged as a potential piece of equipment to use for continuous dry coating pharmaceutical powders. In this work, silicon dioxide was used guest particle on two excipients, fast flow lactose (FFL) and grade PH200 microcrystalline cellulose (MCC), by with modified screen that permitted batch mode operation. Samples were pre-processed in V-blender. SEM images, size distribution, EDS mapping characterise treated Pre-processed samples showed some discrete host particle. After processing, covered complete coating. When processed at high impeller speed, FFL mix A200P fines generated attrition. Continuous samples, which had lower processing time, coated discretely better than samples. Increasing guest/host mass ratio positive impact quality These results help build case time is key parameter success industry.